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Genome: The Autobiography of a Species in 23 Chapters, by Matt Ridley
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The genome's been mapped.
But what does it mean?
Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
- Sales Rank: #13523 in Books
- Published on: 2006-05-30
- Released on: 2006-05-30
- Original language: English
- Number of items: 1
- Dimensions: 8.00" h x .83" w x 5.31" l, .61 pounds
- Binding: Paperback
- 368 pages
Amazon.com Review
Science writer Matt Ridley has found a way to tell someone else's story without being accused of plagiarism. Genome: The Autobiography of a Species in 23 Chapters delves deep within your body (and, to be fair, Ridley's too) looking for dirt dug up by the Human Genome Project. Each chapter pries one gene out of its chromosome and focuses on its role in our development and adult life, but also goes further, exploring the implications of genetic research and our quickly changing social attitudes toward this information. Genome shies away from the "tedious biochemical middle managers" that only a nerd could love and instead goes for the A-material: genes associated with cancer, intelligence, sex (of course), and more.
Readers unfamiliar with the jargon of genetic research needn't fear; Ridley provides a quick, clear guide to the few words and concepts he must use to translate hard science into English. His writing is informal, relaxed, and playful, guiding the reader so effortlessly through our 23 chromosomes that by the end we wish we had more. He believes that the Human Genome Project will be as world-changing as the splitting of the atom; if so, he is helping us prepare for exciting times--the hope of a cure for cancer contrasts starkly with the horrors of newly empowered eugenicists. Anyone interested in the future of the body should get a head start with the clever, engrossing Genome. --Rob Lightner
From Publishers Weekly
HSoon we'll know what's in our genes: next year, the Human Genome Project will have its first-draft map of our 23 chromosomes. Ridley (The Red Queen; The Origins of Virtue) anticipates the genomic news with an inventively constructed, riveting exposition of what we already know about the links between DNA and human life. His inviting prose proposes "to tell the story of the human genome... chromosome by chromosome, by picking a gene from each." That story begins with the basis of life on earth, the DNA-to-RNA-to-protein process (chapter one, "Life," and also chromosome one); the evolution of Homo sapiens (chromosome two, which emerged in early hominids when two ape chromosomes fused); and the discovery of genetic inheritance (which came about in part thanks to the odd ailment called alkaptonuria, carried on chromosome three). Some facts about your life depend entirely on a single gene--for example, whether you'll get the dreadful degenerative disease Huntington's chorea, and if so, at what age (chromosome four, hence chapter four: "Fate"). But most facts about you are products of pleiotropy, "multiple effects of multiple genes," plus the harder-to-study influences of culture and environment. (One asthma-related gene--but only one--hangs out on chromosome five.) The brilliant "whistle-stop tour of some... sites in the genome" passes through "Intelligence," language acquisition, embryology, aging, sex and memory before arriving at two among many bugbears surrounding human genetic mapping: the uses and abuses of genetic screening, and the ongoing debate on "genetic determinism" and free will. Ridley can explain with equal verve difficult moral issues, philosophical quandaries and technical biochemistry; he distinguishes facts from opinions well, and he's not shy about offering either. Among many recent books on genes, behavior and evolution, Ridley's is one of the most informative. It's also the most fun to read. Agent, Felicity Bryan.
Copyright 2000 Reed Business Information, Inc.
From Library Journal
Written in 23 chapters corresponding to the 23 pairs of chromosomes comprising the human genome, this is an engrossing account of the genetic history of our species. Each chapter focuses on a newly discovered gene on each chromosome, tracing its genetic contribution to such areas as human intelligence, personality, sexual behavior, and susceptibility to disease. Ridley (The Red Queen: Sex and the Evolution of Human Nature) is a zoologist-turned-science writer. As the Human Genome Project nears completion (the first findings are expected to be released February 2000), this book will be particularly relevant to lay readers, providing insight into how far we have come and where we are heading in the understanding of our genetic heritage. Recommended for public and academic libraries.
-Leila Fernandez, Steacie Science Lib., York Univ., Toronto
Copyright 2000 Reed Business Information, Inc.
Most helpful customer reviews
1 of 1 people found the following review helpful.
Good introduction, with some minor shortcomings.
By Jim C
A good introduction into the subject matter, but still lacking in some respects. I enjoyed the structure of 23 chapters actin as a biography of sorts on each of the gene pairs. While there is far too much information to be completely covered in a single book, there are a couple of shortcomings that kept this from being as good as I had hoped.
A little more background into the process of extracting and identifying DNA would have been appreciated. Although this information may have not been complete at the time of the original publishing, in 2013 DNA was commonly used in criminal and civil courts, as well as some daytime talk shows.
Secondly, while I can appreciate the author's interjection of humor to lighten some of the heavier passages, it seems to happen too frequently and ends up detracting. In particular, a few analogies seem to be taken a bit too far after the point has been clearly made.
Lastly, the subject of Gene therapy (treatments) could use a better explanation of how the mechanism works to get the altered genes into the code of the patient.
Otherwise, it is an enjoyable read and an good introduction to the subject matter.
0 of 0 people found the following review helpful.
Had the potential to be interesting
By HM
This is one of the most boring books I have read. I am pretty into anything science related, but this book was just not that interesting. I think it was in the way it was written, since the book itself does contain some interesting topics. Each chapter corresponds with a set of chromosomes and a disease/trait associated with that set of chromosomes (ex Ch 21 about Trisomy 21). I truly think I just didn't like the style of story telling in this book. I would've liked to hear more about the disease and about people affected by the disease and less about the writer's own thoughts and stories. My professor did say this was one of his favorite books, but overall my classmates and I disliked this book.
0 of 0 people found the following review helpful.
Fascinating Science
By R Wayne Morgan
A strong biology background is helpful to get the most out of this mind expanding exploration of the new genetics. The resulting leap in understanding is worth the slog. I read many passages twice to comprehend the insights and implications. With the pace of discovery in this area, I can't wait to read the updated volume II.
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